HBV Target gene Detail Information

> TEC Gene Search Result

Gene Information

Gene Name	TEC
Gene ID	7006
Gene Full Name	tec protein tyrosine kinase
Gene Alias	PSCTK4
Transcripts	ENSG00000135605
Virus	HBV
Gene Type	protein coding
HPA Location Info	Plasma membrane;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	P42680
HGNC ID	HGNC:11719
VEGA ID	OTTHUMG00000128623
OMIM ID	600583
String ID	9606.ENSP00000370912
Drugbank ID	BE0009339
Drug (Cytoscape Annotation)	Dasatinib;Bosutinib
PharmGKB ID	PA36436

Target gene [TEC] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1007965	chr18	20		3	23	View
1010111	chr4	11	2		13	View
1404456	chr4	91	31	14	136	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of TEC expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
TEC expression: Low -> High
Lollipop of TEC expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of TEC expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of TEC expression and immune infiltrating cell level correlation result in HBV+ samples
TEC expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).