HBV Target gene Detail Information

> TCL1A Gene Search Result

Gene Information

Gene Name	TCL1A
Gene ID	8115
Gene Full Name	T cell leukemia/lymphoma 1A
Gene Alias	TCL1
Transcripts	ENSG00000100721
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Endoplasmic reticulum;Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	P56279
HGNC ID	HGNC:11648
VEGA ID	OTTHUMG00000171390
OMIM ID	186960
String ID	9606.ENSP00000385036
PharmGKB ID	PA36400

Target gene [TCL1A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1006255	chr14	41			41	View
1007053	chr14	31			31	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of TCL1A expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
TCL1A expression: Low -> High
Lollipop of TCL1A expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of TCL1A expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of TCL1A expression and immune infiltrating cell level correlation result in HBV+ samples
TCL1A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).