HBV Target gene Detail Information

> TCF7L2 Gene Search Result

Gene Information

Gene Name	TCF7L2
Gene ID	6934
Gene Full Name	transcription factor 7 like 2
Gene Alias	TCF4; TCF-4
Transcripts	ENSG00000148737
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;Nuclear bodies;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	Q9NQB0
HGNC ID	HGNC:11641
VEGA ID	OTTHUMG00000019070
OMIM ID	602228
String ID	9606.ENSP00000358404
PharmGKB ID	PA36394

Target gene [TCF7L2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1002700	chr10	113	92	15	220	View
1011545	chr10	8		1	9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of TCF7L2 expression and immune infiltrating cell level correlation result in HBV+ samples
TCF7L2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).