HIV Target gene Detail Information

> TBK1 Gene Search Result

Gene Information

Gene Name	TBK1
Gene ID	29110
Gene Full Name	TANK binding kinase 1
Gene Alias	NAK; T2K; IIAE8; FTDALS4
Transcripts	ENSG00000183735
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Vesicles;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID	Q9UHD2
HGNC ID	HGNC:11584
VEGA ID	OTTHUMG00000168796
OMIM ID	604834
String ID	9606.ENSP00000329967
Drugbank ID	BE0009348
PharmGKB ID	PA36348

Target gene [TBK1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4010786	chr12	6	2		8	View
4011827	chr12	1	5		6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TBK1 expression and immune infiltrating cell level correlation result in HIV+ samples
TBK1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TBK1 expression and immune infiltrating cell level correlation result in HIV+ samples
TBK1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).