HTLV1 Target gene Detail Information

> TBC1D8 Gene Search Result

Gene Information

Gene Name	TBC1D8
Gene ID	11138
Gene Full Name	TBC1 domain family member 8
Gene Alias	AD3; VRP; HBLP1; GRAMD8; TBC1D8A
Transcripts	ENSG00000204634
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nuclear speckles;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	O95759
HGNC ID	HGNC:17791
VEGA ID	OTTHUMG00000153040
String ID	9606.ENSP00000366036
PharmGKB ID	PA134885935

Target gene [TBC1D8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6009721	chr2	15	12	8	35	View
6009886	chr2	15	12	7	34	View
6021175	chr2		5	1	6	View
6030189	chr2	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of TBC1D8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TBC1D8 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of TBC1D8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TBC1D8 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of TBC1D8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TBC1D8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).