HIV Target gene Detail Information

> STK4 Gene Search Result

Gene Information

Gene Name	STK4
Gene ID	6789
Gene Full Name	serine/threonine kinase 4
Gene Alias	KRS2; MST1; YSK3
Transcripts	ENSG00000101109
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear bodies;Cytosol;Nucleoplasm;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID	Q13043
HGNC ID	HGNC:11408
VEGA ID	OTTHUMG00000033059
OMIM ID	604965
String ID	9606.ENSP00000361892
PharmGKB ID	PA36215

Target gene [STK4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000533	chr20	355	27	11	393	View
4001589	chr20	50	93	6	149	View
4002137	chr20	29	47	34	110	View
4004142	chr20	45	3		48	View
4004284	chr20	42	4		46	View
4004358	chr20	36	9		45	View
4004629	chr20	41			41	View
4006195	chr20	22	4		26	View
4006645	chr20	7	15	1	23	View
4006646	chr20	21	2		23	View
4007591	chr20	9	9		18	View
4007854	chr20	16	1		17	View
4010313	chr20	8	1		9	View
4010586	chr20	3	5		8	View
4011604	chr20	6			6	View
4014435	chr20	2			2	View
4015347	chr20	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of STK4 expression and immune infiltrating cell level correlation result in HIV+ samples
STK4 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of STK4 expression and immune infiltrating cell level correlation result in HIV+ samples
STK4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).