HIV Target gene Detail Information

> STAT2 Gene Search Result

Gene Information

Gene Name	STAT2
Gene ID	6773
Gene Full Name	signal transducer and activator of transcription 2
Gene Alias	P113; IMD44; ISGF-3; STAT113
Transcripts	ENSG00000170581
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID	P52630
HGNC ID	HGNC:11363
VEGA ID	OTTHUMG00000170760
OMIM ID	600556
String ID	9606.ENSP00000315768
PharmGKB ID	PA36184

Target gene [STAT2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001684	chr12	133	7		140	View
4009491	chr12	11			11	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of STAT2 expression and immune infiltrating cell level correlation result in HIV+ samples
STAT2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of STAT2 expression and immune infiltrating cell level correlation result in HIV+ samples
STAT2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).