HIV Target gene Detail Information

> ST8SIA4 Gene Search Result

Gene Information

Gene Name	ST8SIA4
Gene ID	7903
Gene Full Name	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Gene Alias	PST; PST1; SIAT8D; ST8SIA-IV
Transcripts	ENSG00000113532
Virus	HIV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q92187
HGNC ID	HGNC:10871
VEGA ID	OTTHUMG00000128727
OMIM ID	602547
String ID	9606.ENSP00000231461
PharmGKB ID	PA35772

Target gene [ST8SIA4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000753	chr5	89	98	122	309	View
4000785	chr5	122	69	92	283	View
4005447	chr5	31	1		32	View
4005540	chr5	31			31	View
4006385	chr5	25			25	View
4007466	chr5	6	13		19	View
4007522	chr5	19			19	View
4008176	chr5	13	3		16	View
4009000	chr5	10	3		13	View
4015547	chr5		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ST8SIA4 expression and immune infiltrating cell level correlation result in HIV+ samples
ST8SIA4 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ST8SIA4 expression and immune infiltrating cell level correlation result in HIV+ samples
ST8SIA4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).