HPV Target gene Detail Information

> SRY Gene Search Result

Gene Information

Gene Name	SRY
Gene ID	6736
Gene Full Name	sex determining region Y
Gene Alias	TDF; TDY; SRXX1; SRXY1
Transcripts	ENSG00000184895
Virus	HPV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID	Q05066
HGNC ID	HGNC:11311
VEGA ID	OTTHUMG00000036084
OMIM ID	480000
PharmGKB ID	PA36135

Target gene [SRY] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	29695285	A7540G	LCR	G R S C	View
2	28767682	C7310T	LCR	G R S C	View
3	28767682	G7826A	LCR	G R S C	View
4	28767682	A7830C	LCR	G R S C	View
5	28767682	A7900C	LCR	G R S C	View
6	24099556	G7193T	LCR	G R C	View
7	24099556	T7201C	LCR	G R C	View
8	24099556	A7339T	LCR	G R C	View
9	24099556	G7553T	LCR	G R C	View
10	24099556	C7930T	LCR	G R C	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of SRY expression and immune infiltrating cell level correlation result in HPV+ samples
SRY expression: Low -> High

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of SRY expression and immune infiltrating cell level correlation result in HPV+ samples
SRY expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of SRY expression and immune infiltrating cell level correlation result in HPV+ samples
SRY expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of SRY expression and immune infiltrating cell level correlation result in HPV+ samples
SRY expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of SRY expression and immune infiltrating cell level correlation result in HPV+ samples
SRY expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of SRY expression and immune infiltrating cell level correlation result in HPV+ samples
SRY expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of SRY expression and immune infiltrating cell level correlation result in HPV+ samples
SRY expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662