HIV Target gene Detail Information

> SRPK1 Gene Search Result

Gene Information

Gene Name	SRPK1
Gene ID	6732
Gene Full Name	SRSF protein kinase 1
Gene Alias	SFRSK1
Transcripts	ENSG00000096063
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Plasma membrane;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q96SB4
HGNC ID	HGNC:11305
VEGA ID	OTTHUMG00000014583
OMIM ID	601939
String ID	9606.ENSP00000362931
PharmGKB ID	PA36129

Target gene [SRPK1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001576	chr6	128	21	1	150	View
4005992	chr6	18	5	5	28	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SRPK1 expression and immune infiltrating cell level correlation result in HIV+ samples
SRPK1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SRPK1 expression and immune infiltrating cell level correlation result in HIV+ samples
SRPK1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).