HIV Target gene Detail Information

> SREBF2 Gene Search Result

Gene Information

Gene Name	SREBF2
Gene ID	6721
Gene Full Name	sterol regulatory element binding transcription factor 2
Gene Alias	SREBP2; bHLHd2; SREBP-2
Transcripts	ENSG00000198911
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Vesicles;Endoplasmic reticulum;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Uniport_ID	Q12772
HGNC ID	HGNC:11290
VEGA ID	OTTHUMG00000151261
OMIM ID	600481
String ID	9606.ENSP00000354476
PharmGKB ID	PA336

Target gene [SREBF2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002950	chr22	71	3		74	View
4003301	chr22	58	6		64	View
4004375	chr22	38	7		45	View
4004961	chr22	33	4		37	View
4005410	chr22	27	6		33	View
4009845	chr22	7	3		10	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SREBF2 expression and immune infiltrating cell level correlation result in HIV+ samples
SREBF2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).