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HIV Target gene Detail Information

> SPTLC2 Gene Search Result


Gene Information
Gene Name SPTLC2
Gene ID 9517
Gene Full Name serine palmitoyltransferase long chain base subunit 2
Gene Alias LCB2; SPT2; HSN1C; LCB2A; NSAN1C; hLCB2a
Transcripts ENSG00000100596
Virus HIV
Gene Type protein coding
HPA Location Info Mitochondria;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins
Uniport_ID O15270
HGNC ID HGNC:11278
VEGA ID OTTHUMG00000171540
OMIM ID 605713
String ID 9606.ENSP00000216484
Drugbank ID BE0000660
PharmGKB ID PA36107
Target gene [SPTLC2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4003343 chr14 44 16 3 63 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of SPTLC2 expression and immune infiltrating cell level correlation result in HIV+ samples
SPTLC2 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of SPTLC2 expression and immune infiltrating cell level correlation result in HIV+ samples
SPTLC2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).