HBV Target gene Detail Information

> SPRED2 Gene Search Result

Gene Information

Gene Name	SPRED2
Gene ID	200734
Gene Full Name	sprouty related EVH1 domain containing 2
Gene Alias	Spred-2
Transcripts	ENSG00000198369
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q7Z698
HGNC ID	HGNC:17722
VEGA ID	OTTHUMG00000152737
OMIM ID	609292
String ID	9606.ENSP00000348753
PharmGKB ID	PA134956365

Target gene [SPRED2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1001348	chr2	117	354	295	766	View
1001349	chr2	117	354	295	766	View
1401455	chr2	117	354	295	766	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of SPRED2 expression and immune infiltrating cell level correlation result in HBV+ samples
SPRED2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).