HIV Target gene Detail Information

> SPRED1 Gene Search Result

Gene Information

Gene Name	SPRED1
Gene ID	161742
Gene Full Name	sprouty related EVH1 domain containing 1
Gene Alias	NFLS; hSpred1; spred-1; PPP1R147
Transcripts	ENSG00000166068
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q7Z699
HGNC ID	HGNC:20249
VEGA ID	OTTHUMG00000172377
OMIM ID	609291
String ID	9606.ENSP00000299084
PharmGKB ID	PA134897382

Target gene [SPRED1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4010399	chr15	6	3		9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SPRED1 expression and immune infiltrating cell level correlation result in HIV+ samples
SPRED1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SPRED1 expression and immune infiltrating cell level correlation result in HIV+ samples
SPRED1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).