HIV Target gene Detail Information

> SPPL2B Gene Search Result

Gene Information

Gene Name	SPPL2B
Gene ID	56928
Gene Full Name	signal peptide peptidase like 2B
Gene Alias	IMP4; PSH4; PSL1; IMP-4
Transcripts	ENSG00000005206
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Plasma membrane;Centrosome;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted membrane proteins
Uniport_ID	Q8TCT7
HGNC ID	HGNC:30627
VEGA ID	OTTHUMG00000180443
OMIM ID	608239
String ID	9606.ENSP00000478298
PharmGKB ID	PA166049002

Target gene [SPPL2B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005845	chr19	14	13	2	29	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SPPL2B expression and immune infiltrating cell level correlation result in HIV+ samples
SPPL2B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).