HIV Target gene Detail Information

> SPOP Gene Search Result

Gene Information

Gene Name	SPOP
Gene ID	8405
Gene Full Name	speckle type BTB/POZ protein
Gene Alias	TEF2; BTBD32
Transcripts	ENSG00000121067
Virus	HIV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	O43791
HGNC ID	HGNC:11254
VEGA ID	OTTHUMG00000161496
OMIM ID	602650
String ID	9606.ENSP00000377001
PharmGKB ID	PA36084

Target gene [SPOP] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001325	chr17	121	51	6	178	View
4004657	chr17	35	6		41	View
4004658	chr17	41			41	View
4005945	chr17	28			28	View
4007144	chr17	6		15	21	View
4016249	chr17				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SPOP expression and immune infiltrating cell level correlation result in HIV+ samples
SPOP expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SPOP expression and immune infiltrating cell level correlation result in HIV+ samples
SPOP expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).