HTLV1 Target gene Detail Information

> SPEG Gene Search Result

Gene Information

Gene Name	SPEG
Gene ID	10290
Gene Alias	BPEG; CNM5; APEG1; MYLK6; APEG-1; SPEGbeta; SPEGalpha
Transcripts	ENSG00000072195
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Vesicles;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q15772
HGNC ID	HGNC:16901
VEGA ID	OTTHUMG00000058925
OMIM ID	615950
String ID	9606.ENSP00000311684
PharmGKB ID	PA142672598

Target gene [SPEG] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6009151	chr2	39			39	View
6020045	chr2	5	2		7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of SPEG expression and immune infiltrating cell level correlation result in HTLV1+ samples
SPEG expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of SPEG expression and immune infiltrating cell level correlation result in HTLV1+ samples
SPEG expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).