HIV Target gene Detail Information

> SPC25 Gene Search Result

Gene Information

Gene Name	SPC25
Gene ID	57405
Gene Full Name	SPC25, NDC80 kinetochore complex component
Gene Alias	AD024; SPBC25; hSpc25
Transcripts	ENSG00000277909
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9HBM1
HGNC ID	HGNC:24031
VEGA ID	OTTHUMG00000175310
OMIM ID	609395
String ID	9606.ENSP00000282074
PharmGKB ID	PA162404413

Target gene [SPC25] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4006752	chr2	15	8		23	View
4010535	chr2	1	7		8	View
4011022	chr2		7		7	View
4011023	chr2		7		7	View
4012034	chr2		5		5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SPC25 expression and immune infiltrating cell level correlation result in HIV+ samples
SPC25 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SPC25 expression and immune infiltrating cell level correlation result in HIV+ samples
SPC25 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).