HBV Target gene Detail Information

> SPAST Gene Search Result

Gene Information

Gene Name	SPAST
Gene ID	6683
Gene Full Name	spastin
Gene Alias	FSP2; SPG4; ADPSP
Transcripts	ENSG00000021574
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q9UBP0
HGNC ID	HGNC:11233
VEGA ID	OTTHUMG00000128455
OMIM ID	604277
String ID	9606.ENSP00000480893
PharmGKB ID	PA36063

Target gene [SPAST] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1014374	chr2		3		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of SPAST expression and immune infiltrating cell level correlation result in HBV+ samples
SPAST expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).