HPV Target gene Detail Information

> SPARC Gene Search Result

Gene Information

Gene Name	SPARC
Gene ID	6678
Gene Full Name	secreted protein acidic and cysteine rich
Gene Alias	ON; OI17; BM-40
Transcripts	ENSG00000113140
Virus	HPV
Gene Type	protein coding
HPA Location Info	Vesicles;Predicted to be secreted;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Gene Function	Suppressor gene & Oncogene
Uniport_ID	P09486
HGNC ID	HGNC:11219
VEGA ID	OTTHUMG00000130122
OMIM ID	182120
String ID	9606.ENSP00000231061
Drugbank ID	BE0002145
PharmGKB ID	PA36055

Target gene [SPARC] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5300505	chr5	16	2		18	View
5300506	chr5	17	2		19	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE40774 (GEO)	Head and neck squamous cell carcinoma	134	Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE138080 (GEO)	Cervical intraepithelial neoplasia	25	Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE40774
HeatMap of cell type fractions in all samples	Lollipop of SPARC expression and immune infiltrating cell level correlation result in HPV+ samples
SPARC expression: Low -> High

> Dataset: GSE138080
HeatMap of cell type fractions in all samples	Lollipop of SPARC expression and immune infiltrating cell level correlation result in HPV+ samples
SPARC expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of SPARC expression and immune infiltrating cell level correlation result in HPV+ samples
SPARC expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).