HIV Target gene Detail Information

> SP1 Gene Search Result

Gene Information

Gene Name	SP1
Gene ID	6667
Gene Full Name	Sp1 transcription factor
Transcripts	ENSG00000185591
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID	P08047
HGNC ID	HGNC:11205
VEGA ID	OTTHUMG00000170047
OMIM ID	189906
String ID	9606.ENSP00000329357
PharmGKB ID	PA36042

Target gene [SP1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000481	chr17	219	189	26	434	View
4000766	chr2	34	216	37	287	View
4002237	chr12	70	3	31	104	View
4002272	chr12	102			102	View
4003076	chr12	41	14	15	70	View
4004281	chr17	45	1		46	View
4005554	chr12	25	4	2	31	View
4006883	chr2	21	1		22	View
4007464	chr5	19			19	View
4007871	chr11	16	1		17	View
4010837	chr17	8			8	View
4010865	chr20	2	4	2	8	View
4012213	chr12	3	2		5	View
4013630	chr17	3			3	View
4014710	chr17	2			2	View
4016087	chr17				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SP1 expression and immune infiltrating cell level correlation result in HIV+ samples
SP1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SP1 expression and immune infiltrating cell level correlation result in HIV+ samples
SP1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).