HPV Target gene Detail Information

> SOX10 Gene Search Result

Gene Information

Gene Name	SOX10
Gene ID	6663
Gene Full Name	SRY-box 10
Gene Alias	DOM; WS4; PCWH; WS2E; WS4C
Transcripts	ENSG00000100146
Virus	HPV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID	P56693
HGNC ID	HGNC:11190
VEGA ID	OTTHUMG00000149913
OMIM ID	602229
String ID	9606.ENSP00000380093
PharmGKB ID	PA36027

Target gene [SOX10] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	29695285	C7265G	LCR	G R S C	View
2	29695285	C7266T	LCR	G R S C	View
3	32677948	A7376G	LCR	G C	View
4	32677948	T7791A	LCR	G C	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of SOX10 expression and immune infiltrating cell level correlation result in HPV+ samples
SOX10 expression: Low -> High

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of SOX10 expression and immune infiltrating cell level correlation result in HPV+ samples
SOX10 expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of SOX10 expression and immune infiltrating cell level correlation result in HPV+ samples
SOX10 expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of SOX10 expression and immune infiltrating cell level correlation result in HPV+ samples
SOX10 expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of SOX10 expression and immune infiltrating cell level correlation result in HPV+ samples
SOX10 expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of SOX10 expression and immune infiltrating cell level correlation result in HPV+ samples
SOX10 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of SOX10 expression and immune infiltrating cell level correlation result in HPV+ samples
SOX10 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662