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HPV Target gene Detail Information

> SOST Gene Search Result


Gene Information
Gene Name SOST
Gene ID 50964
Gene Full Name sclerostin
Gene Alias CDD; VBCH; DAND6; SOST1
Transcripts ENSG00000167941
Virus HPV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Disease related genes, Predicted secreted proteins
Uniport_ID Q9BQB4
HGNC ID HGNC:13771
VEGA ID OTTHUMG00000180888
OMIM ID 605740
String ID 9606.ENSP00000301691
Drugbank ID BE0009557
PharmGKB ID PA37809
Target gene [SOST] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5402558 chr17 6 2 8 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of SOST expression and immune infiltrating cell level correlation result in HPV+ samples
SOST expression: Low -> High

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of SOST expression and immune infiltrating cell level correlation result in HPV+ samples
SOST expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of SOST expression and immune infiltrating cell level correlation result in HPV+ samples
SOST expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of SOST expression and immune infiltrating cell level correlation result in HPV+ samples
SOST expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).