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HPV Target gene Detail Information

> SMPDL3B Gene Search Result


Gene Information
Gene Name SMPDL3B
Gene ID 27293
Gene Full Name sphingomyelin phosphodiesterase acid like 3B
Gene Alias ASML3B
Transcripts ENSG00000130768
Virus HPV
Gene Type protein coding
HPA Location Info Cytosol;Golgi apparatus;Predicted to be secreted;
HPA Protein Class Info Predicted secreted proteins
Uniport_ID Q92485
HGNC ID HGNC:21416
VEGA ID OTTHUMG00000003910
OMIM ID 617737
String ID 9606.ENSP00000363001
PharmGKB ID PA134889099
Target gene [SMPDL3B] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5002362 chr1 3 6 3 12 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of SMPDL3B expression and immune infiltrating cell level correlation result in HPV+ samples
SMPDL3B expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of SMPDL3B expression and immune infiltrating cell level correlation result in HPV+ samples
SMPDL3B expression: Low -> High

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of SMPDL3B expression and immune infiltrating cell level correlation result in HPV+ samples
SMPDL3B expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of SMPDL3B expression and immune infiltrating cell level correlation result in HPV+ samples
SMPDL3B expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of SMPDL3B expression and immune infiltrating cell level correlation result in HPV+ samples
SMPDL3B expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of SMPDL3B expression and immune infiltrating cell level correlation result in HPV+ samples
SMPDL3B expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of SMPDL3B expression and immune infiltrating cell level correlation result in HPV+ samples
SMPDL3B expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of SMPDL3B expression and immune infiltrating cell level correlation result in HPV+ samples
SMPDL3B expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of SMPDL3B expression and immune infiltrating cell level correlation result in HPV+ samples
SMPDL3B expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).