HIV Target gene Detail Information

> SMCHD1 Gene Search Result

Gene Information

Gene Name	SMCHD1
Gene ID	23347
Gene Full Name	structural maintenance of chromosomes flexible hinge domain containing 1
Gene Alias	BAMS; FSHD2
Transcripts	ENSG00000101596
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Nuclear bodies;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	A6NHR9
HGNC ID	HGNC:29090
VEGA ID	OTTHUMG00000178235
OMIM ID	614982
String ID	9606.ENSP00000326603
PharmGKB ID	PA128395776

Target gene [SMCHD1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000180	chr18	42	431	338	811	View
4003977	chr18	33	18		51	View
4004219	chr18	47			47	View
4008007	chr18	9	8		17	View
4010151	chr18	9			9	View
4010962	chr18	8			8	View
4012925	chr18	2	1	1	4	View
4013103	chr18	2		2	4	View
4014170	chr18	1	1		2	View
4014717	chr18	1	1		2	View
4014718	chr18	2			2	View
4016255	chr18				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SMCHD1 expression and immune infiltrating cell level correlation result in HIV+ samples
SMCHD1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SMCHD1 expression and immune infiltrating cell level correlation result in HIV+ samples
SMCHD1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).