HIV Target gene Detail Information

> SMC3 Gene Search Result

Gene Information

Gene Name	SMC3
Gene ID	9126
Gene Full Name	structural maintenance of chromosomes 3
Gene Alias	BAM; BMH; HCAP; CDLS3; CSPG6; SMC3L1
Transcripts	ENSG00000108055
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q9UQE7
HGNC ID	HGNC:2468
VEGA ID	OTTHUMG00000019042
OMIM ID	606062
String ID	9606.ENSP00000354720
PharmGKB ID	PA26966

Target gene [SMC3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002892	chr10	71	5		76	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SMC3 expression and immune infiltrating cell level correlation result in HIV+ samples
SMC3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SMC3 expression and immune infiltrating cell level correlation result in HIV+ samples
SMC3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).