HBV Target gene Detail Information

> SMAD5 Gene Search Result

Gene Information

Gene Name	SMAD5
Gene ID	4090
Gene Full Name	SMAD family member 5
Gene Alias	DWFC; JV5-1; MADH5
Transcripts	ENSG00000113658
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins, Transcription factors
Uniport_ID	Q99717
HGNC ID	HGNC:6771
VEGA ID	OTTHUMG00000163212
OMIM ID	603110
String ID	9606.ENSP00000441954
PharmGKB ID	PA30528

Target gene [SMAD5] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1001271	chr5	36	449	348	833	View
1001528	chr5	36	325	284	645	View
1004916	chr5	53	8	5	66	View
1004918	chr5	53	8	5	66	View
1004919	chr5	53	8	5	66	View
1007802	chr5	23	1		24	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of SMAD5 expression and immune infiltrating cell level correlation result in HBV+ samples
SMAD5 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).