HIV Target gene Detail Information

> SMAD4 Gene Search Result

Gene Information

Gene Name	SMAD4
Gene ID	4089
Gene Full Name	SMAD family member 4
Gene Alias	JIP; DPC4; MADH4; MYHRS
Transcripts	ENSG00000141646
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Centrosome;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	Q13485
HGNC ID	HGNC:6770
VEGA ID	OTTHUMG00000132696
OMIM ID	600993
String ID	9606.ENSP00000341551
PharmGKB ID	PA30527

Target gene [SMAD4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001857	chr18	32	8	86	126	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SMAD4 expression and immune infiltrating cell level correlation result in HIV+ samples
SMAD4 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SMAD4 expression and immune infiltrating cell level correlation result in HIV+ samples
SMAD4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).