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HBV Target gene Detail Information

> SMAD3 Gene Search Result


Gene Information
Gene Name SMAD3
Gene ID 4088
Gene Full Name SMAD family member 3
Gene Alias LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436
Transcripts ENSG00000166949
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;Cytosol;
HPA Protein Class Info Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID P84022
HGNC ID HGNC:6769
VEGA ID OTTHUMG00000133230
OMIM ID 603109
String ID 9606.ENSP00000332973
PharmGKB ID PA30526
Target gene [SMAD3] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 29609638 A181T
RT
 View

Target gene [SMAD3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1019677 chr15 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of SMAD3 expression and immune infiltrating cell level correlation result in HBV+ samples
SMAD3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).