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HBV Target gene Detail Information

> SMAD2 Gene Search Result


Gene Information
Gene Name SMAD2
Gene ID 4087
Gene Full Name SMAD family member 2
Gene Alias JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2
Transcripts ENSG00000175387
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Nucleoli;Nucleoplasm;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Gene Function Suppressor gene
Uniport_ID Q15796
HGNC ID HGNC:6768
VEGA ID OTTHUMG00000132652
OMIM ID 601366
String ID 9606.ENSP00000262160
Drugbank ID BE0004445
PharmGKB ID PA134959722
Target gene [SMAD2] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 29609638 A181T
RT
 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of SMAD2 expression and immune infiltrating cell level correlation result in HBV+ samples
SMAD2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).