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HIV Target gene Detail Information

> SLK Gene Search Result


Gene Information
Gene Name SLK
Gene ID 9748
Gene Full Name STE20 like kinase
Gene Alias LOSK; STK2; se20-9; bA16H23.1
Transcripts ENSG00000065613
Virus HIV
Gene Type protein coding
HPA Location Info Cytosol;Plasma membrane;
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID Q9H2G2
HGNC ID HGNC:11088
VEGA ID OTTHUMG00000018999
OMIM ID 616563
String ID 9606.ENSP00000358770
Drugbank ID BE0004041
PharmGKB ID PA35941
Target gene [SLK] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4004925 chr10 9 24 5 38 View
4008593 chr10 2 12 14 View
4013139 chr10 4 4 View
4014327 chr10 2 2 View
4014328 chr10 2 2 View
4016560 chr10 0 View
4016749 chr10 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of SLK expression and immune infiltrating cell level correlation result in HIV+ samples
SLK expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of SLK expression and immune infiltrating cell level correlation result in HIV+ samples
SLK expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).