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HBV Target gene Detail Information

> SLIT3 Gene Search Result


Gene Information
Gene Name SLIT3
Gene ID 6586
Gene Full Name slit guidance ligand 3
Gene Alias MEGF5; SLIL2; SLIT1; slit2; Slit-3
Transcripts ENSG00000184347
Virus HBV
Gene Type protein coding
HPA Location Info Cell Junctions;Predicted to be secreted;
HPA Protein Class Info Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID O75094
HGNC ID HGNC:11087
VEGA ID OTTHUMG00000130409
OMIM ID 603745
String ID 9606.ENSP00000332164
PharmGKB ID PA35940
Target gene [SLIT3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1005877 chr5 19 27 46 View
1006247 chr5 41 41 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of SLIT3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
SLIT3 expression: Low -> High
Lollipop of SLIT3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of SLIT3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of SLIT3 expression and immune infiltrating cell level correlation result in HBV+ samples
SLIT3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).