HBV Target gene Detail Information

> SLCO1B3 Gene Search Result

Gene Information

Gene Name	SLCO1B3
Gene ID	28234
Gene Full Name	solute carrier organic anion transporter family member 1B3
Gene Alias	LST3; HBLRR; LST-2; OATP8; OATP-8; OATP1B3; SLC21A8; LST-3TM13
Transcripts	ENSG00000111700
Virus	HBV
Gene Type	protein coding
HPA Location Info	Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Uniport_ID	Q9NPD5
HGNC ID	HGNC:10961
VEGA ID	OTTHUMG00000169011
OMIM ID	605495
String ID	9606.ENSP00000261196
Drugbank ID	BE0003659
Drug (Cytoscape Annotation)	Paclitaxel
PharmGKB ID	PA35844

Target gene [SLCO1B3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1004977	chr12	50	14	1	65	View
1013523	chr12	5			5	View
1016723	chr12		1		1	View
1017463	chr12	1			1	View
1019742	chr12				0	View
1019746	chr12				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of SLCO1B3 expression and immune infiltrating cell level correlation result in HBV+ samples
SLCO1B3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).