HPV Target gene Detail Information

> SLC6A15 Gene Search Result

Gene Information

Gene Name	SLC6A15
Gene ID	55117
Gene Full Name	solute carrier family 6 member 15
Gene Alias	V7-3; NTT73; SBAT1; hv7-3
Transcripts	ENSG00000072041
Virus	HPV
Gene Type	protein coding
HPA Location Info	Nucleoli;Vesicles;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	Q9H2J7
HGNC ID	HGNC:13621
VEGA ID	OTTHUMG00000169742
OMIM ID	607971
String ID	9606.ENSP00000266682
PharmGKB ID	PA37799

Target gene [SLC6A15] related to VISs

DVID	Chromosome	HM	Sum of Overlapped Records	Detail
5200166	chr12		0	View
5403049	chr12	3	3	View
5404342	chr12		0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of SLC6A15 expression and immune infiltrating cell level correlation result in HPV+ samples
SLC6A15 expression: Low -> High

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of SLC6A15 expression and immune infiltrating cell level correlation result in HPV+ samples
SLC6A15 expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of SLC6A15 expression and immune infiltrating cell level correlation result in HPV+ samples
SLC6A15 expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of SLC6A15 expression and immune infiltrating cell level correlation result in HPV+ samples
SLC6A15 expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of SLC6A15 expression and immune infiltrating cell level correlation result in HPV+ samples
SLC6A15 expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of SLC6A15 expression and immune infiltrating cell level correlation result in HPV+ samples
SLC6A15 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of SLC6A15 expression and immune infiltrating cell level correlation result in HPV+ samples
SLC6A15 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662