HTLV1 Target gene Detail Information

> SLC5A2 Gene Search Result

Gene Information

Gene Name	SLC5A2
Gene ID	6524
Gene Full Name	solute carrier family 5 member 2
Gene Alias	SGLT2
Transcripts	ENSG00000140675
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, FDA approved drug targets, Predicted membrane proteins, Transporters
Uniport_ID	P31639
HGNC ID	HGNC:11037
VEGA ID	OTTHUMG00000176620
OMIM ID	182381
String ID	9606.ENSP00000327943
Drugbank ID	BE0004753
PharmGKB ID	PA35902

Target gene [SLC5A2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000585	chr16	946	161	76	1183	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of SLC5A2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SLC5A2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of SLC5A2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SLC5A2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of SLC5A2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SLC5A2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).