HIV Target gene Detail Information

> SLC25A46 Gene Search Result

Gene Information

Gene Name	SLC25A46
Gene ID	91137
Gene Full Name	solute carrier family 25 member 46
Gene Alias	HMSN6B
Transcripts	ENSG00000164209
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	Q96AG3
HGNC ID	HGNC:25198
VEGA ID	OTTHUMG00000128794
OMIM ID	610826
String ID	9606.ENSP00000348211
PharmGKB ID	PA162403737

Target gene [SLC25A46] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003536	chr5	47	12		59	View
4010336	chr5	9			9	View
4011776	chr5	6			6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SLC25A46 expression and immune infiltrating cell level correlation result in HIV+ samples
SLC25A46 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SLC25A46 expression and immune infiltrating cell level correlation result in HIV+ samples
SLC25A46 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).