HIV Target gene Detail Information

> SLC12A2 Gene Search Result

Gene Information

Gene Name	SLC12A2
Gene ID	6558
Gene Full Name	solute carrier family 12 member 2
Gene Alias	BSC; BSC2; NKCC1; PPP1R141
Transcripts	ENSG00000064651
Virus	HIV
Gene Type	protein coding
HPA Location Info	Vesicles;Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	FDA approved drug targets, Predicted membrane proteins, Transporters
Uniport_ID	P55011
HGNC ID	HGNC:10911
VEGA ID	OTTHUMG00000128983
OMIM ID	600840
String ID	9606.ENSP00000262461
Drugbank ID	BE0000281
PharmGKB ID	PA35806

Target gene [SLC12A2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4011331	chr5	7			7	View
4014810	chr5		2		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SLC12A2 expression and immune infiltrating cell level correlation result in HIV+ samples
SLC12A2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SLC12A2 expression and immune infiltrating cell level correlation result in HIV+ samples
SLC12A2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).