HBV Target gene Detail Information

> SKP2 Gene Search Result

Gene Information

Gene Name	SKP2
Gene ID	6502
Gene Full Name	S-phase kinase associated protein 2
Gene Alias	p45; FBL1; FLB1; FBXL1
Transcripts	ENSG00000145604
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins
Gene Function	Suppressor gene & Oncogene
Uniport_ID	Q13309
HGNC ID	HGNC:10901
VEGA ID	OTTHUMG00000131106
OMIM ID	601436
String ID	9606.ENSP00000274255
PharmGKB ID	PA35801

Target gene [SKP2] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	21704589	T1753A	BCP	G	View
2	21704589	T1768A	BCP	G	View
3	25567052	G1764A	BCP	G	View
4	25567052	T1753A	BCP	G	View
5	27779207	A1762T	BCP	C	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of SKP2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
SKP2 expression: Low -> High
Lollipop of SKP2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of SKP2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of SKP2 expression and immune infiltrating cell level correlation result in HBV+ samples
SKP2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE114783