HIV Target gene Detail Information

> SIRT3 Gene Search Result

Gene Information

Gene Name	SIRT3
Gene ID	23410
Gene Full Name	sirtuin 3
Gene Alias	SIR2L3
Transcripts	ENSG00000142082
Virus	HIV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q9NTG7
HGNC ID	HGNC:14931
VEGA ID	OTTHUMG00000119074
OMIM ID	604481
String ID	9606.ENSP00000372191
Drugbank ID	BE0004547
PharmGKB ID	PA37936

Target gene [SIRT3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000318	chr11	434	83	31	548	View
4000619	chr11	9	297	35	341	View
4000917	chr11	12	215	22	249	View
4004323	chr11	46			46	View
4008454	chr11	15			15	View
4008913	chr11	8	4	1	13	View
4012045	chr11	1	4		5	View
4012046	chr11	1	4		5	View
4012194	chr11	5			5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SIRT3 expression and immune infiltrating cell level correlation result in HIV+ samples
SIRT3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).