HBV Target gene Detail Information

> SIM1 Gene Search Result

Gene Information

Gene Name	SIM1
Gene ID	6492
Gene Full Name	SIM bHLH transcription factor 1
Gene Alias	bHLHe14
Transcripts	ENSG00000112246
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nuclear speckles;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Transcription factors
Uniport_ID	P81133
HGNC ID	HGNC:10882
VEGA ID	OTTHUMG00000015275
OMIM ID	603128
String ID	9606.ENSP00000358210
PharmGKB ID	PA35782

Target gene [SIM1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1002581	chr6	215	16	12	243	View
1402705	chr6	215	16	12	243	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of SIM1 expression and immune infiltrating cell level correlation result in HBV+ samples
SIM1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).