HIV Target gene Detail Information

> SIK3 Gene Search Result


Gene Information
Gene Name SIK3
Gene ID 23387
Gene Full Name SIK family kinase 3
Gene Alias L19; QSK; SEMDK; SIK-3
Transcripts ENSG00000160584
Virus HIV
Gene Type protein coding
HPA Location Info Nucleoplasm;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Predicted intracellular proteins, Predicted membrane proteins
HGNC ID HGNC:29165
VEGA ID OTTHUMG00000066628
OMIM ID 614776
String ID 9606.ENSP00000364449
Drugbank ID BE0009408
PharmGKB ID PA165543631
Target gene [SIK3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4000621 chr11 62 46 232 340 View
4000643 chr11 191 132 11 334 View
4003129 chr11 48 17 4 69 View
4006072 chr11 23 4 27 View
4009644 chr11 11 11 View
4012202 chr11 5 5 View
4013844 chr11 2 1 3 View
4015233 chr11 1 1 View
4015503 chr11 1 1 View
4015951 chr11 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of SIK3 expression and immune infiltrating cell level correlation result in HIV+ samples
SIK3 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of SIK3 expression and immune infiltrating cell level correlation result in HIV+ samples
SIK3 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).