Home
Virus
Gene
Disease
Dataset
Download
Help
 
HBV Target gene Detail Information

> SIAH1 Gene Search Result


Gene Information
Gene Name SIAH1
Gene ID 6477
Gene Full Name siah E3 ubiquitin protein ligase 1
Gene Alias SIAH1A
Transcripts ENSG00000196470
Virus HBV
Gene Type protein coding
HPA Location Info Mitochondria;Nucleoplasm;
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins
Gene Function Suppressor gene
Uniport_ID Q8IUQ4
HGNC ID HGNC:10857
VEGA ID OTTHUMG00000175417
OMIM ID 602212
String ID 9606.ENSP00000349156
PharmGKB ID PA35759
Target gene [SIAH1] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 17622616 P101S
X
 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of SIAH1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
SIAH1 expression: Low -> High
Lollipop of SIAH1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of SIAH1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of SIAH1 expression and immune infiltrating cell level correlation result in HBV+ samples
SIAH1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).