EBV Target gene Detail Information

> SHB Gene Search Result

Gene Information

Gene Name	SHB
Gene ID	6461
Gene Full Name	SH2 domain containing adaptor protein B
Gene Alias	bA3J10.2
Transcripts	ENSG00000107338
Virus	EBV
Gene Type	protein coding
HPA Location Info	Cytosol;Cytoplasmic bodies;Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q15464
HGNC ID	HGNC:10838
VEGA ID	OTTHUMG00000019936
OMIM ID	600314
String ID	9606.ENSP00000366936
PharmGKB ID	PA35744

Target gene [SHB] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
3000535	chr9	12			12	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE102203 (GEO)	B-cell lymphoma	9	Plasmablastic lymphomas (EBV+)(6), Plasmablastic lymphomas (EBV-)(3)
GSE100458 (GEO)	Burkitt lymphoma	14	Burkitt lyphoma cell line Akata(EBV+)(2),Burkitt lyphoma cell line Akata(EBV-)(2),Burkitt lyphoma cell line Awia(EBV+)(2),Burkitt lyphoma cell line Awia(EBV-)(2),Burkitt lyphoma cell line Eli(EBV+)(1),Burkitt lyphoma cell line Eli(EBV-)(1),Burkitt lyphoma cell line Mutu(EBV+)(2),Burkitt lyphoma cell line Mutu(EBV-)(2)
GSE42867 (GEO)	Burkitt lymphoma	12	Burkitt lymphoma cell line Awia (EBV+)(12)
GSE135644 (GEO)	Gastric carcinoma	10	Gastric adenocarcinoma cell line AGS (5), Gastric adenocarcinoma cell line AGS (EBV+)(5)
GSE45919 (GEO)	Infectious mononucleosis	24	Infectious mononucleosis (IM)(EBV+)(3), Normal (9), Latent EBV (12)
GSE85599 (GEO)	Infectious mononucleosis	17	Chronic active EBV infection (EBV+)(5), Acute infectious mononucleosis (EBV+)(6), Normal (6)
GSE58240 (GEO)	Multiple sclerosis	32	Multiple sclerosis IFN-β treated (EBV+)(16), Multiple sclerosis untreated (EBV+)(16)
GSE12452 (GEO)	Nasopharyngeal carcinoma	41	Nasopharyngeal carcinoma (EBV+)(31), Normal(10)

> Dataset: GSE102203
HeatMap of cell type fractions in all samples	Lollipop of SHB expression and immune infiltrating cell level correlation result in EBV+ samples
SHB expression: Low -> High

> Dataset: GSE100458
HeatMap of cell type fractions in all samples	Lollipop of SHB expression and immune infiltrating cell level correlation result in EBV+ samples
SHB expression: Low -> High

> Dataset: GSE42867
HeatMap of cell type fractions in all samples	Lollipop of SHB expression and immune infiltrating cell level correlation result in EBV+ samples
SHB expression: Low -> High

> Dataset: GSE135644
HeatMap of cell type fractions in all samples	Lollipop of SHB expression and immune infiltrating cell level correlation result in EBV+ samples
SHB expression: Low -> High

> Dataset: GSE45919
HeatMap of cell type fractions in all samples	Lollipop of SHB expression and immune infiltrating cell level correlation result in EBV+ samples
SHB expression: Low -> High

> Dataset: GSE85599
HeatMap of cell type fractions in all samples	Lollipop of SHB expression and immune infiltrating cell level correlation result in EBV+ samples
SHB expression: Low -> High

> Dataset: GSE58240
HeatMap of cell type fractions in all samples	Lollipop of SHB expression and immune infiltrating cell level correlation result in EBV+ samples
SHB expression: Low -> High

> Dataset: GSE12452
HeatMap of cell type fractions in all samples	Lollipop of SHB expression and immune infiltrating cell level correlation result in EBV+ samples
SHB expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE102203