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HBV Target gene Detail Information

> SHANK2 Gene Search Result


Gene Information
Gene Name SHANK2
Gene ID 22941
Gene Full Name SH3 and multiple ankyrin repeat domains 2
Gene Alias SHANK; AUTS17; CORTBP1; CTTNBP1; ProSAP1; SPANK-3
Transcripts ENSG00000162105
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;Nuclear speckles;Vesicles;
HPA Protein Class Info Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID Q9UPX8
HGNC ID HGNC:14295
VEGA ID OTTHUMG00000154615
OMIM ID 603290
String ID 9606.ENSP00000469689
PharmGKB ID PA37867
Target gene [SHANK2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001218 chr11 237 286 378 901 View
1005486 chr11 45 8 53 View
1007755 chr11 14 6 4 24 View
1008899 chr11 16 2 18 View
1010740 chr11 10 1 11 View
1011828 chr11 5 3 8 View
1403510 chr11 16 2 18 View
1403632 chr11 45 8 53 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of SHANK2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
SHANK2 expression: Low -> High
Lollipop of SHANK2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of SHANK2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of SHANK2 expression and immune infiltrating cell level correlation result in HBV+ samples
SHANK2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).