HBV Target gene Detail Information

> SH2B3 Gene Search Result

Gene Information

Gene Name	SH2B3
Gene ID	10019
Gene Full Name	SH2B adaptor protein 3
Gene Alias	LNK; IDDM20
Transcripts	ENSG00000111252
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q9UQQ2
HGNC ID	HGNC:29605
VEGA ID	OTTHUMG00000169550
OMIM ID	605093
String ID	9606.ENSP00000345492
Drugbank ID	BE0004714
PharmGKB ID	PA145148124

Target gene [SH2B3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1006564	chr12	19	15	2	36	View
1006979	chr12	19	12		31	View
1403958	chr12	19	15	2	36	View
1403959	chr12	19	12		31	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of SH2B3 expression and immune infiltrating cell level correlation result in HBV+ samples
SH2B3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).