HTLV1 Target gene Detail Information

> SGMS2 Gene Search Result

Gene Information

Gene Name	SGMS2
Gene ID	166929
Gene Full Name	sphingomyelin synthase 2
Gene Alias	SMS2
Transcripts	ENSG00000164023
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q8NHU3
HGNC ID	HGNC:28395
VEGA ID	OTTHUMG00000131811
OMIM ID	611574
String ID	9606.ENSP00000378176
PharmGKB ID	PA162403069

Target gene [SGMS2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6001230	chr4	502	16	5	523	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of SGMS2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SGMS2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of SGMS2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SGMS2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).