HIV Target gene Detail Information

> SF3B3 Gene Search Result

Gene Information

Gene Name	SF3B3
Gene ID	23450
Gene Full Name	splicing factor 3b subunit 3
Gene Alias	RSE1; SAP130; SF3b130; STAF130
Transcripts	ENSG00000189091
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoli;Nucleoli rim;Nucleoplasm;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q15393
HGNC ID	HGNC:10770
VEGA ID	OTTHUMG00000137582
OMIM ID	605592
String ID	9606.ENSP00000305790
Drugbank ID	BE0008945
PharmGKB ID	PA35688

Target gene [SF3B3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4011210	chr16	5	2		7	View
4013383	chr16	3			3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SF3B3 expression and immune infiltrating cell level correlation result in HIV+ samples
SF3B3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SF3B3 expression and immune infiltrating cell level correlation result in HIV+ samples
SF3B3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).