HIV Target gene Detail Information

> SF3B2 Gene Search Result

Gene Information

Gene Name	SF3B2
Gene ID	10992
Gene Full Name	splicing factor 3b subunit 2
Gene Alias	Cus1; SF3b1; SAP145; SF3B145; SF3b150
Transcripts	ENSG00000087365
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear speckles;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q13435
HGNC ID	HGNC:10769
VEGA ID	OTTHUMG00000166751
OMIM ID	605591
String ID	9606.ENSP00000318861
PharmGKB ID	PA35687

Target gene [SF3B2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002913	chr11	39	36		75	View
4006553	chr11	24			24	View
4006772	chr11	22	1		23	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SF3B2 expression and immune infiltrating cell level correlation result in HIV+ samples
SF3B2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SF3B2 expression and immune infiltrating cell level correlation result in HIV+ samples
SF3B2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).