HIV Target gene Detail Information

> SESN1 Gene Search Result

Gene Information

Gene Name	SESN1
Gene ID	27244
Gene Full Name	sestrin 1
Gene Alias	PA26; SEST1
Transcripts	ENSG00000080546
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoli fibrillar center;Nucleoplasm;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q9Y6P5
HGNC ID	HGNC:21595
VEGA ID	OTTHUMG00000015338
OMIM ID	606103
String ID	9606.ENSP00000393762
PharmGKB ID	PA134927596

Target gene [SESN1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005444	chr6	17	7	8	32	View
4006169	chr6	15	6	5	26	View
4006834	chr6	7	2	13	22	View
4008181	chr6	7	8	1	16	View
4009590	chr6	11			11	View
4015432	chr6		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SESN1 expression and immune infiltrating cell level correlation result in HIV+ samples
SESN1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SESN1 expression and immune infiltrating cell level correlation result in HIV+ samples
SESN1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).