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HBV Target gene Detail Information

> SERPINC1 Gene Search Result


Gene Information
Gene Name SERPINC1
Gene ID 462
Gene Full Name serpin family C member 1
Gene Alias AT3; AT3D; ATIII; THPH7; ATIII-R2
Transcripts ENSG00000117601
Virus HBV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins
Uniport_ID P01008
HGNC ID HGNC:775
VEGA ID OTTHUMG00000037276
OMIM ID 107300
String ID 9606.ENSP00000356671
Drugbank ID BE0000280
PharmGKB ID PA35026
FDA Approved Drug Avatrombopag;Eltrombopag;Estradiol;Progesterone;Lusutrombopag;Synthetic Conjugated Estrogens,A
Target gene [SERPINC1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1004330 chr1 32 49 4 85 View
1012299 chr1 7 7 View
1400447 chr1 7 2 9 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of SERPINC1 expression and immune infiltrating cell level correlation result in HBV+ samples
SERPINC1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).